Home - Products - Chromatin/Epigenetic - COX - Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate

Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate

CAS No. 68-89-3

Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate( Dipyrone )

Catalog No. M15634 CAS No. 68-89-3

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 49 In Stock
10MG 68 In Stock
25MG 111 In Stock
50MG 162 In Stock
100MG 227 In Stock
200MG 336 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate
  • Note
    Research use only, not for human use.
  • Brief Description
    A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine.
  • Description
    A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable.
  • In Vitro
    Cell Proliferation Assay Cell Line:PaTu 8988 t, Panc-1 Concentration: 1, 10, 100, 250, 500 μM Incubation Time:48 hours Result:Inhibited proliferation in the PaTu 8988 t cell line with 1–500 μM and with concentrations of 1 μM,10 μM, 100 μM, and 250 μM in the Panc-1 cell line.Increased the apoptosis rate after 9 h.
  • In Vivo
    Animal Model:Male Wistar rats (270-300 g), with peripheral neuropathic painDosage:500 mg/kg Administration:Intraperitoneal injection, twice a day, for 7 days Result:Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.Animal Model:Pain model in rats Dosage:250 or 500 mg/kg Administration: p.o.Result:Decreased the COX-2 gene expression at 500 mg/kg and increased the MPO gene expression.Reduced MDA levels in the carrageenan paw test and increased tGSH levels.
  • Synonyms
    Dipyrone
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX-1
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    68-89-3
  • Formula Weight
    333.34
  • Molecular Formula
    C13H16N3NaO4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)([O-])=O.[Na+]
  • Chemical Name
    Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jage J, et al. Anaesthesist. 2008 Apr;57(4):382-90.
molnova catalog
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